Well, I guess it was inevitable. Somebody named Tim Collins has written something called The Little Book Of Twitter which summarizes classic works in 140 characters or less.

Great Expectations: Orphan given £££ by secret follower. He thinks it's @misshavisham but it turns out to be @magwitch.

Ulysses: Man walks around Dublin. We follow every minute detail of his day. He's probably overtweeting.

Waiting for Godot: Vladimir and Estragon stand next to tree and wait for Godot. Their status is not updated.

I'll give you one off the top of my head. The Bible: Omniscient, all-powerful being decides to communicate via foliage.